Explore by health topic
View allGLP-1
Semaglutide, tirzepatide, retatrutide, side effects, dosing, and access.
Peptides
Recovery, metabolism, skin health, and evidence-based peptide guides.
Drug Guides
Plain-language coverage of major GLP-1 medications and comparisons.
Diet & Side Effects
Food, protein, fiber, nausea, fatigue, reflux, and long-term routines.
Latest
New guides from Middleway
Peptides
VIP Nasal Spray for CIRS: Protocol, Evidence, Dosing and Cost
VIP nasal spray is the last step of the Shoemaker CIRS protocol. Here is what the one long-term study found, how the spray is dosed and monitored, and what it costs.
Peptides
PT-141 vs Viagra: Desire, Erections and What the Evidence Shows
PT-141 acts on desire circuits in the brain; Viagra boosts blood flow once arousal starts. How they differ in onset, evidence, side effects and legal status.
Peptides
PT-141 for Women: What Vyleesi Does, Who It's For, and the Real Trial Numbers
PT-141 is approved for women as Vyleesi, a 1.75 mg autoinjector for low desire before menopause. Here is what the trials showed, the side effects, and who it doesn't cover.
GLP-1
Phentermine vs Semaglutide: Weight Loss, Side Effects, Cost and Who Each Suits
Semaglutide produced about 15% weight loss over 68 weeks; phentermine is a cheap short-term stimulant with smaller results. How they differ on safety, cost and stopping.
Peptides
KPV vs BPC-157: Which Peptide Fits Gut Inflammation, IBD and Leaky Gut?
KPV damps inflammatory signalling inside gut cells; BPC-157 is framed as a tissue-repair peptide. Both rest on animal data. Here is how they compare for the gut.
Peptides
How to Reconstitute HCG: Mixing Chart, Steps and Storage
How to mix a 5,000 or 10,000 IU HCG vial: which diluent, how much water, the IU-per-unit maths for a U-100 syringe, and how long the mixed vial lasts.
Peptides
HCG Diet: The 500-Calorie Protocol, What the Trials Found, and What Replaced It
The HCG diet pairs a pregnancy hormone with 500 calories a day. Controlled trials found the hormone adds nothing. Here is the protocol, the evidence and the risks.
Peptides
GHK-Cu vs Retinol: Mechanisms, Evidence, and How to Use Both
Retinoids have decades of trials and an FDA-approved form. GHK-Cu is gentler but rests on small studies. How they differ, and how to layer them safely.
Peptides
FOXO4-DRI vs Fisetin: Which Senolytic Has the Better Evidence?
FOXO4-DRI is a mouse-only peptide; fisetin is a cheap flavonoid with Mayo trials still running. How they compare with dasatinib plus quercetin, and what is unknown.