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View allGLP-1
Semaglutide, tirzepatide, retatrutide, side effects, dosing, and access.
Peptides
Recovery, metabolism, skin health, and evidence-based peptide guides.
Drug Guides
Plain-language coverage of major GLP-1 medications and comparisons.
Diet & Side Effects
Food, protein, fiber, nausea, fatigue, reflux, and long-term routines.
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New guides from Middleway
GLP-1
WVE-007 (James Bond Peptide): What It Is and Why the Nickname Is Wrong
It is not a peptide, and the Bond reference comes from a gene rather than a film. What is genuinely interesting about it is the muscle question.
GLP-1
Petrelintide & Eloralintide: What These Amylin Analogues Are and Where They Stand
Two once weekly amylin drugs aiming for GLP-1 style weight loss with far less nausea. Both are in trials, neither is available, and the tolerability claim is the point.
GLP-1
NA-931 (Bioglutide): What It Is and How Much of the Claim Is Verified
An oral four-receptor agonist would be a genuine advance if it works. Here is what is actually established about it, and what rests on company statements alone.
Peptides
Humanin Peptide: What It Is, and How Much the Evidence Supports
A 24 amino acid peptide encoded inside mitochondrial DNA, discovered in an Alzheimer's screen. Genuinely interesting biology, and almost entirely preclinical evidence.
Peptides
How to Use Peptides: Dosage, Mixing and Injection, Step by Step
A practical walkthrough of using research peptides: mixing the vial, converting milligrams to syringe units, injecting subcutaneously, and the errors that cause wrong doses.
GLP-1
Brenipatide: What It Is, Why It Is Monthly, and What Is Not Yet Known
A once-monthly GLP-1 and GIP agonist aimed at addiction and psychiatric conditions rather than obesity. The strategy is interesting. The efficacy data does not exist yet.
GLP-1
Aleniglipron (GSBR-1290): What It Is and Where the Trials Stand
Aleniglipron is an oral GLP-1 receptor agonist that is not a peptide at all. What that difference means, what phase 2 showed, and what phase 3 is testing.
GLP-1
Albiglutide (Tanzeum): What It Was and Why It Disappeared
The once-weekly GLP-1 that worked, sold for three years, and was withdrawn for commercial reasons. What it did, why it lost, and what a patient would take instead.
Peptides
AICAR Peptide Benefits: What AMPK Activation Actually Delivers
AICAR activates AMPK and produced striking endurance results in mice. Whether any of that translates to humans is a separate question, and the dose maths is the problem.